Osteogenesis imperfecta, often known as brittle bone disease, is a hereditary condition that manifests as weak, easily fractured bones before birth. It is caused by a genetic mutation in the genes coding for collagen produced by bone-forming cells (osteoblasts). Collagen is essential for the development of bones and skin; therefore, the presence of a mutation results in aberrant or inadequate collagen, which lowers bone mass and strength. During development, unspecialized cells (stem cells) assist in the formation of the body. In response to stimuli from the microenvironment, stem cells migrate and differentiate into various cell types with varying functions, creating organs and tissues. Most of our organs still have a modest number of stem cells, which are utilized in later life to treat acute injury-related tissue damage and restore organ function. The building blocks of the body also include these cells. Researchers like Dr. David Greene Arizona have investigated using endogenous ...
A certified Otolaryngologist (ENT) and Facial Plastic Surgeon, David Greene MD has over 20 years of surgical and clinical experience. Dr. Greene is trained from Harvard, Yale, Stanford, and the University of California and has studied and taught at some of the best academic institutions of the world.