Many scientists and researchers like Dr. David Arizona have developed numerous medications and therapies for incurable diseases and damages in the last decade. Humans are one of the most robust species grown in thousands of years. We developed technology by which we can win over most of the problems around us. But somewhere, we lose, and that’s nature who always comes up with a new lesson to teach us what we are doing right or wrong.
Heart issues are common nowadays in every age group. That was the time when only older people used to have heart problems. Now, even children have these issues, and every year, over one million people die from different heart diseases. This data is snowballing, and this has become one of the significant issues in the world right now. Conditions like heart failure, high blood pressure, heart attack, and many more destroy many lives among every age group.
Whenever someone has just survived a massive heart stroke or attack, their health condition gets very crucial and sensitive. This is because, in most cases, there is a sudden blockage of arteries after a heart attack, leading to irregular heartbeats, arrhythmia, and ultimately, heart failure.
Repairing the heart after so much damage after an attack has been proven to be vital, and scientists have been trying to do that over the last decade. There are two perspectives among the researcher; some focus on repairing the damage perfectly, while others are more inclined towards protecting the heart from any severe attack. Dr. David Greene Arizona has already predicted that stem cell therapy will be proven as the future of medical science and orthopedics for most diseases.
A team of scientists from the University of California has developed a way to use a common type of stem cell called Bone marrow-derived cells (BMCs) in heart conditions. Research also showed that this method effectively repairs the heart after a severe heart attack. But unfortunately, this experiment couldn’t be observed well in the clinic, and scientists are working on why this happened.
Previously, the experiment was done on the mice, and the study showed made the team believe that BMCs were the most impaired if they were collected within a week of a heart attack but should be back to normal by a few weeks. The observation was successfully seen in the mice but didn’t translate in the human cells. Human BMCs taken three weeks after a heart attack were just as ineffective at repairing heart damage as those taken immediately after the heart attack.
Coming back to the new method, the scientists observed that those BMCs used in the clinical trials were just taken after the heart attack. A heart attack creates a significant impact on the body, which could have affected the BMCs. In the mouse experiment, those BMCs were derived from healthy mice and showed the desired result. They concluded that BMCs derived from a post-heart attack body are ineffective for repairing heart damage than BMCs from a healthy donor.
Dr. David Greene Orthopedic Surgeon is one of the very few people who see the real potential of regenerative medicines and stem cell therapies. Also, he has been working on that for the last decade with his organization.
Furthermore, the researchers worked to observe the composition of healthy versus post-heart attack BMCs. The experiment clearly showed that there was a change in the cellular composition after a heart attack. Analysis of miRNAs, critical regulatory molecules that can act as biomarkers, showed a pro-inflammatory profile. When the heart attack induces some inflammatory response in bone marrow, only the team observed that this could be why the BMCs are ineffective compared to healthy donors' BMCs.
After all the efforts of the scientists, the research showed that there is a difference between the recovery rate through BMCs of humans and mice. Moreover, other studies have also found out that the factor limiting the BMCs' therapeutic effect is the change in cellular composition, especially the loss of specific B-cells.
This points to the need for future clinical trials to use healthy BMC donors rather than using a patient’s BMCs to heal heart damage. There is a need for more experiments and corrections for this to be applied to humans, but with the leaders like Dr. David Greene Arizona, that day is not that far.
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